Touch Designer would be best option if you already have a copy. Be aware of the limitations of Notch playback depending the Touch Designer license type.
I don’t know if this is the right workflow.
I came up with a solution to switch the layers inside a notch block based on an OSC command triggered by timecode.
In your experience is it better to switch different effects by switching layers inside the block, or to switch different blocks? Or is this dependent on the media server that is being used?